Table 1.
Summary of some of the candidate gene methylations for schizophrenia.
| Candidate Gene | Gene Location | Encoded Protein | Major Function | Reference |
|---|---|---|---|---|
| GAD1 | 2q31.1 | Glutamate decarboxylase-67 | Conversion of glutamic acid to GABA | [67] |
| COMT | 22q11 | Catechol-O-methyltransferase | Monoamine metabolism | [68] |
| RELN | 7q22 | Reelin | Cellular maturation and synaptic function | [69] |
| BDNF | 11p13–14 | Brain Derived Neurotrophic Factor | Survival and differentiation of neuronal population | [70] |
| CHRNA7 | 15q13.3 | Nicotinic acetylcholine receptor | Cholinergic synaptic transmission | [71] |
| SOX10 | 22q13.1 | SRY-box 10 | Nucleocytoplasmic shuttle in the development nervous system | [72] |
| EGR1 | 5q31.2 | Early growth response protein 1 | Transcriptional regulator in neuronal development | [73] |
GABA-gamma aminobutyric acid, SRY-sex determining region Y.