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. 2021 Oct 21;10(11):2836. doi: 10.3390/cells10112836

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Disease-specific modification of miR17-92 expression by TGF-β1 and treprostinil. Cells were treated with either TGF-β1 (10 ng/mL), or treprostinil (10⁻⁸ M) alone, or combination of both (T + T). MiR expression was determined after 24 h for guide and passenger strands. Relative expression of miR17-92 in (A) cells of controls (n = 7); (B) IPF patients (n = 7); and (C) interstitial lung fibrosis patients (n = 5). Bars represent mean ± SEM. * indicates p < 0.05. TGFβ: TGF-β1 (10 ng/mL); Tre: treprostinil (1 × 10⁻⁸ M); T+T: TGF-β1 (10 ng/mL) plus treprostinil (1 × 10⁻⁸ M).

Disease-specific modification of miR17-92 expression by TGF-β1 and treprostinil. Cells were treated with either TGF-β1 (10 ng/mL), or treprostinil (10⁻⁸ M) alone, or combination of both (T + T). MiR expression was determined after 24 h for guide and passenger strands. Relative expression of miR17-92 in (A) cells of controls (n = 7); (B) IPF patients (n = 7); and (C) interstitial lung fibrosis patients (n = 5). Bars represent mean ± SEM. * indicates p < 0.05. TGFβ: TGF-β1 (10 ng/mL); Tre: treprostinil (1 × 10⁻⁸ M); T+T: TGF-β1 (10 ng/mL) plus treprostinil (1 × 10⁻⁸ M).