Table 2.
Applied Erasmus-iCycle wish-list. Dp = prescribed dose, 60/66/70 Gy; different logarithmic tumor control probability (LTCP) settings were used depending on Dp. Note that the goal value for constraints was set slightly stricter than the actual clinical limit to account for finite sampling resolution.
| Priority | Volume | Type | Goal | Sufficient |
|---|---|---|---|---|
| Constraint | PTV | Max | Dp · 1.02 | |
| Constraint | PTV | Mean | Dp · 0.997 | |
| Constraint | Spinal canal | Max | 47 Gy | |
| Constraint | Brachial plexus | Max | 60 Gy | |
| Constraint | Shell PTV + 1 cm 1 | Max | Dp | |
| Constraint | Shell PTV + 7 cm 1 | Max | Dp · 0.75 | |
| Constraint | External ring 2 | Max | Dp · 0.8 | |
| 1 | PTV | ↓ LTCP 3 | 0.14/0.12/0.12 | 0.14/0.12/0.12 |
| 2 | Lungs | ↓ Mean | 19 Gy | |
| 3 | Shell PTV + 3 mm 1 | ↓ Max | Dp | Dp |
| 4 | Shell PTV + 1 cm 1 | ↓ Max | Dp · 0.9 | Dp · 0.9 |
| 5 | Shell PTV + 7 cm 1 | ↓ Max | Dp · 0.65 | |
| 6 | Lungs | ↓ Mean | 13 Gy | |
| 7 | Heart | ↓ Mean | 13 Gy | |
| 8 | Esophagus | ↓ Mean | 18 Gy | |
| 9 | Shell PTV + 3 cm 1 | ↓ Max | Dp · 0.75 | |
| 10 | Shell PTV + 7 cm 1 | ↓ Max | Dp · 0.55 | |
| 11 | Lungs | ↓ Mean | 0 Gy | |
| 12 | Heart | ↓ Mean | 0 Gy | |
| 13 | Esophagus | ↓ Mean | 0 Gy |
1 Shells consist of all pixels located at the specified distance from the PTV. 2 Ring structure extending 2 cm inside the patient surface, subtracting PTV + 4 cm. 3 Logarithmic tumor control probability (LTCP) as defined in [10], using prescription Dp · 0.95 and α = 0.85/0.8/0.8.