Table 1.

Phenotypes of Ang-Tie2 knockout mice.

Genotype	Phenotype	References
Tie1−/−	Lethality between E13.5 and birth; loss of vascular integrity and maturity; widespread edema and hemorrhaging	[19]
Tie2−/−	Embryonic lethality between E9.5 and E12.5; vessel remodeling defects in the brain and plexus of the yolk sac; severe heart defects; decreased numbers of vascular ECs; poorly organized vessels with fewer branches and less pericyte coverage	[3,16,17,18,22]
Tie1−/−; Tie2−/−	Embryonic lethality at E10.5; vasculature develops normally; cardiovascular defects; loss of vascular integrity and maturity	[21]
Ang1−/−	Embryonic lethality between E11 and E12.5; growth-retarded hearts; collapsed endocardium and endothelial lining in the atria; immature primary plexus; decreased pericyte coverage of vessels	[16]
Ang2−/−	Lethality by postnatal day P14; chylous ascites develop a few days after birth; severe vascular defects including collapsed endocardial lining from the myocardium and disruption of vascular integrity; impaired response to inflammatory challenges	[23,24]