Table 1.
Results of Molecular Complex Detection (MCODE) analysis performed on upregulated and downregulated differentially expressed proteins in first episode psychosis (FEP) and/or first episode schizophrenia (FES).
| MCODE Components | GO ID | Biological Term | Log10 (p) |
|---|---|---|---|
| Upregulated genes in FEP, MCODE1 (Biological GO terms) | GO:0032496 | response to lipopolysaccharide | −41.6 |
| GO:0006954 | inflammatory response | −40.8 | |
| GO:0002237 | response to molecule of bacterial origin | −40.8 | |
| Upregulated genes in FEP, MCODE2 (GO, PANTHER, KEGG, WikiPaths) | R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway | −10.1 |
| R-HSA-73887 | death receptor signaling | −9.8 | |
| R-HSA-75893 | TNF signaling | −9.4 | |
| Downregulated genes in FEP, MCODE1 (Biological GO terms) | GO:0048011 | neurotrophin TRK receptor signaling pathway | −22.5 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | −22.1 | |
| GO:0032989 | cellular component morphogenesis | −21.8 | |
| Downregulated genes in FEP, MCODE2 (Biological GO terms) | GO:0016246 | RNA interference | −15.6 |
| GO:0035196 | production of miRNAs involved in gene silencing by miRNA | −15.5 | |
| GO:0070918 | production of small RNA involved in gene silencing by RNA | −15.3 | |
| All seed genes in FEP/FES, MCODE1 (Biological GO terms) | GO:0001774 | microglial cell activation | −13.2 |
| GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | −12.3 | |
| GO:0042509 | regulation of tyrosine phosphorylation of STAT protein | −11.8 |