Table 2.
Biological GO term classifications of differently expressed proteins in first episode psychosis or schizophrenia.
| Top Genes |
GO Term ID | GO Term Definition | P |
p FDR Adjusted |
Number of Genes |
|---|---|---|---|---|---|
| Complement factors | |||||
| 1 | GO:0098883 | synapse pruning | 1.00 × 10−10 | 1.41 × 10−6 | 3 |
| 2 | GO:0030449 | regulation of complement activation | 2.02 × 10−10 | 1.11 × 10−3 | 3 |
| 3 | GO:0002920 | regulation of humoral immune response | 3.18 × 10−7 | 1.17 × 10−3 | 3 |
| 4 | GO:0006958 | complement activation, classical pathway | 5.40 × 10−7 | 1.30 × 10−3 | 3 |
| 5 | GO:0002455 | humoral immune response mediated by circulating immunoglobulin | 5.92 × 10−7 | 1.30 × 10−3 | 3 |
| 6 | GO:0006956 | complement activation | 7.29 × 10−7 | 1.34 × 10−3 | 3 |
| 7 | GO:0016064 | immunoglobulin mediated immune response | 1.08 × 10−6 | 1.56 × 10−3 | 3 |
| 8 | GO:0019724 | B cell mediated immunity | 1.13 × 10−6 | 1.56 × 10−3 | 3 |
| 9 | GO:0002449 | lymphocyte mediated immunity | 2.35 × 10−6 | 2.66 × 10−3 | 3 |
| 10 | GO:0050808 | synapse organization | 2.46 × 10−6 | 2.66 × 10−3 | 3 |
| DISC1 | |||||
| 1 | GO:0021799 | cerebral cortex radially oriented cell migration | 1.13 × 10−8 | 1.25 × 10−4 | 3 |
| 2 | GO:0021795 | cerebral cortex cell migration | 3.82 × 10−8 | 1.40 × 10−4 | 3 |
| 3 | GO:0045773 | positive regulation of axon extension | 3.82 × 10−8 | 1.40 × 10−4 | 3 |
| 4 | GO:0022029 | telencephalon cell migration | 9.56 × 10−8 | 2.46 × 10−4 | 3 |
| 5 | GO:0021885 | forebrain cell migration | 1.11 × 10−7 | 2.46 × 10−4 | 3 |
| 6 | GO:0021954 | central nervous system neuron development | 2.54 × 10−7 | 4.67 × 10−4 | 3 |
| 7 | GO:0050772 | positive regulation of axonogenesis | 3.06 × 10−7 | 4.81 × 10−4 | 3 |
| 8 | GO:0030516 | regulation of axon extension | 4.42 × 10−7 | 6.09 × 10−4 | 3 |
| 9 | GO:0061387 | regulation of extent of cell growth | 6.67 × 10−7 | 8.17 × 10−4 | 3 |
| 10 | GO:0021987 | cerebral cortex development | 7.83 × 10−7 | 8.48 × 10−4 | 3 |
| DROSCHA | |||||
| 1 | GO:0031053 | primary miRNA processing | 1.84 × 10−7 | 2.03 × 10−3 | 2 |
| 2 | GO:0010586 | miRNA metabolic process | 1.18 × 10−6 | 5.95 × 10−3 | 2 |
| 3 | GO:0035196 | production of miRNAs involved in gene silencing by miRNA | 2.08 × 10−6 | 5.95 × 10−3 | 2 |
| 4 | GO:0070918 | production of small RNA involved in gene silencing by RNA | 2.70 × 10−6 | 5.95 × 10−3 | 2 |
| 5 | GO:0031050 | dsRNA processing | 2.70 × 10−6 | 5.95 × 10−3 | 2 |