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. 2021 Oct 28;10(11):2937. doi: 10.3390/cells10112937

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A simplified diagram of the synthesis of steroid hormones and neurosteroids. DHEA—dehydroepiandrosterone; DHEA-S—dehydroepiandrosterone sulfate; CYP11A1—mitochondrial cholesterol side-chain cleavage enzyme; StAR—steroidogenic acute-regulatory protein; 3β-HSD—3β-hydroxysteroid dehydrogenase; CYP17-hydroxylase/17,20-lyase; CYP19—aromatase; 17β-HSD—17β-hydroxysteroid dehydrogenases; 3α-HSD—3α-hydroxysteroid oxidoreductase. Sex steroids are presented in blue boxes whereas neurosteroids are featured in red boxes.