Figure 2.

Loss of Gfi1 is associated with a dramatic increase in proliferation rate within the acinar compartment. Measurement of pancreas weight normalized to animal body weight at birth and 3 adult ages. (n = 8 animals per genotype per (st) age) (** p < 0.01, *** p < 0.001) (A). Adult Pdx1Cre::Gfi1cko and controls were provided with BrdU for 5 days. Subsequently, pancreatic sections were analyzed by immunofluorescence. Objective magnification: 20×. Scale bar: 100 μm (B,C). Quantitative analyses of BrdU-labelled cells in different pancreatic compartments (n = 4 animals per genotype) (*** p < 0.001) (D).