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. 2021 Oct 20;10(11):2805. doi: 10.3390/cells10112805

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Ghrelin is misexpressed in Pdx1Cre::Gfi1cko adult pancreas. Immunohistochemical assessment of ghrelin-labeled cells in 3-month-old Pdx1Cre::Gfi1cko adult acinar cells. Objective magnification: 10×. Scale bar: 100 μm (A,B). Immunohistochemical analyses of amylase- and ghrelin-expressing cells in Gfi1-deficient pancreatic tissue. Objective magnification: 20×. Scale bar: 20 μm (C). Quantification of amylase and ghrelin co-immunoexpressing cells in Gfi1-deficient pancreatic acinar compartment (n = 253 ghrelin⁺ cells) (E). Phenotypical evaluations of ghrelin and BrdU labelled cells by immunofluorescence in Pdx1Cre::Gficko adult pancreas. Objective magnification: 20×. Scale bar: 50 μm (D). Quantitative evaluation of pancreatic ghrelin expression by RT-qPCR at different developmental and adult (st)ages (n = 5 animals per genotype per (st) age) (*** p < 0.001) (F).

Ghrelin is misexpressed in Pdx1Cre::Gfi1cko adult pancreas. Immunohistochemical assessment of ghrelin-labeled cells in 3-month-old Pdx1Cre::Gfi1cko adult acinar cells. Objective magnification: 10×. Scale bar: 100 μm (A,B). Immunohistochemical analyses of amylase- and ghrelin-expressing cells in Gfi1-deficient pancreatic tissue. Objective magnification: 20×. Scale bar: 20 μm (C). Quantification of amylase and ghrelin co-immunoexpressing cells in Gfi1-deficient pancreatic acinar compartment (n = 253 ghrelin⁺ cells) (E). Phenotypical evaluations of ghrelin and BrdU labelled cells by immunofluorescence in Pdx1Cre::Gficko adult pancreas. Objective magnification: 20×. Scale bar: 50 μm (D). Quantitative evaluation of pancreatic ghrelin expression by RT-qPCR at different developmental and adult (st)ages (n = 5 animals per genotype per (st) age) (*** p < 0.001) (F).