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. 2021 Oct 20;10(11):2805. doi: 10.3390/cells10112805

Figure 6.

Figure 6

Pdx1Cre::Gfi1cko mice are resistant to high-fat/high-sugar diet-induced hyperglycemia. Basal glycemia was assessed in control and Gfi1-deficient mice (n = 8) at different ages. (*** p < 0.001) (A). Control and Gfi1 mutant mice were fed with HFCD (n = 7 animals per genotype) and their glycemia was monitored for 5 months. (* p < 0.05, ** p < 0.01) (B). Semiquantitative assessment of fecal saccharides by mass spectrometry was performed using samples of Pdx1Cre::Gfi1cko mice and controls fed with chow diet (C) and HFCD (D). (chow diet, n = 11 for control and 16 for Pdx1Cre::Gfi1cko samples; HFCG, n = 5 for control and 12 for Pdx1Cre::Gfi1cko samples) (* p < 0.05).