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HCC morpho-phenotypical features according to the severity of hepatitis.
| Tumor Features | Grade ≥ 3 Hepatitis (N = 7) | Grade 0–2 Hepatitis (N = 20) | p |
|---|---|---|---|
| Grade ≥ 3 | 2 (28%) | 7 (35%) | 1 |
| Necrosis | 3 (42%) | 3 (15%) | 0.290 |
| TLS | 0 | 3 (15%) | 0.545 |
| VETC | 5 (71%) | 13/19 (68%) | 1 |
| Exclusion class | 7 (100%) | 16 (80%) | 1 |
| Immune class | 0 | 4 (20%) | 0.545 |
| AFP > 400 ng/mL | 2/5 (40%) | 3/15 (20%) | 0.545 |
Abbreviations: TLS, intratumor tertiary lymphoid structures; VETC, vessels encapsulating tumor clusters; AFP, alpha-fetoprotein.
