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. 2021 Nov 5;10(11):3037. doi: 10.3390/cells10113037

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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HIV-1 Tg animals exhibited a progressive decrease in dendritic spine volume. (A) The 75th percentile of dendritic spine volume was derived from the distribution of dendritic spines (X ± 95% confidence intervals). HIV-1 Tg animals exhibited a linear decrease in dendritic spine volume across development, whereas control animals displayed an age-related linear increase in dendritic spine volume. (B) Examination of the distribution of dendritic spine volume in HIV-1 Tg and control animals as a function of age confirmed the observations inferred from the 75th percentile of dendritic spine volume.