Table 2.
Population data of the selected articles: a total of 462 subjects underwent teeth extractions after RT.
| Study | Study Design | Included Patients | Mean Age | Mean Follow-Up | RT Technique | Mean Dose § |
Patients Receiving Tooth Extraction | Cases of ORN | ORN Due to Tooth Extraction | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tot | M | F | Years | Months | EBR | IMRT | BT | Gy | n. | n. | n. | ||
| Morrish et al., 1981 [19] | R | 100 | 60 | 40 | 65 | 23 | 100 | 0 | 0 | 66 | 18 | 22 | 9 a |
| Beumer et al., 1983 [15] | R | 72 | - | - | - | * | 72 | 0 | 0 | - | 72 | 16 | 16 a |
| Marx et al., 1985 [20] | RCT | 74 | - | - | - | * | - | - | - | 68 | 74 | 13 | 13 b |
| Epstein et al., 1987 [21] | R | 146 | 103 | 43 | 54.7 | 60 | 140 | 0 | 6 | - | 54 | 8 | 3 a |
| Maxymiw et al., 1991 [12] | P | 72 | - | - | 57.4 | 57.6 | 72 | 0 | 0 | 50 | 72 | 0 | 0 b |
| Lambert et al., 1997 [22] | R | 47 | - | - | - | 35.3 | - | - | - | 60.6 | 46 | 0 | 0 b |
| David et al., 2001 [23] | R | 24 | 13 | 11 | 61 | 10.3 | - | - | - | - | 24 | 0 | 0 b |
| Ben-David et al., 2007 [14] | R | 176 | 128 | 48 | 55 | 35 | 0 | 176 | 0 | 54.6 | 13 | 0 | 0 c |
| Al-Bazie et al., 2016 [11] | R | 89 | 55 | 34 | 41.8 | 63 | - | - | - | 65.4 | 89 | 0 | 0 b |
* Although it was not possible to identify a mean value, the study was included because every patient received a follow-up of at least six months. § The prescribed dose to the tissues affected by the neoplasm. a Bone exposure longer than 3 months. b Bone exposure longer than 6 months. c Bone exposure is present in 2 consecutive follow-ups (6–8 weeks for the first two years, 3–4 months after the first 2 years). Abbreviations: Tot, Total; M, Male; F, Female; n., number; RCT, Randomized Clinical Trial; P, prospective; R, Retrospective; RT, radiotherapy; ORN, osteoradionecrosis; EBR, External Beam Radiotherapy; IMRT, Intensity Modulated Radiation Therapy; BT, Brachytherapy; Gy, Gray.