Table 1.
Differential protein expression of Ba/F3-ITD (G613E) cells after incubation with either 1 μg/mL tunicamycin or 1 mM VPA for 48 h. Whole proteome analysis was performed in triplets by liquid chromatography–tandem mass spectrometry (LC-MS). All indicated fold changes were statistically significant (p < 0.05) while red and green colored illustrating down- and upregulation, respectively.
| Protein | “Fold Change” | Function of Protein | |
|---|---|---|---|
| Tunicamycin | Calreticulin | 3.11 | Chaperone complex in endoplasmatic reticulum |
| HSP90beta1 | 2.53 | ||
| Calnexin | 1.63 | ||
| RAS GTPase protein binding protein2 | 0.55 | Signal transduction | |
| MAPK1/2 | 0.51 | ||
| Endoplasmic reticulum-Golgi intermediate compartment protein1 | 0.45 | Protein transport ER to GA | |
| VPA | Protein kinase C delta type | 1.69 | Signal transduction |
| Nuclear factor NF-kappa B p105 subunit | 1.64 | Transcription factor | |
| Eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1) | 0.59 | Translation | |
| Cyclin-dependent kinase4 (CDK4) | 0.66 | Cell cycle | |
| E3 ubiquitin-protein ligase NEDD4 | 0.64 | Degradation of membrane receptors |