Table 1.

Overview of factors released from platelet α-granules [15,16,17,18,19,20]. The α-granule degranulates upon activation of the platelet, which may occur in cases of stress, disease, or normal haemostatic function in formation of the platelet plug.

	Factors Released from α-Granules
Adhesion proteins	Fibrinogen Fibronectin Thrombospondin Vitronectin von Willebrand factor
Chemokines	Connective tissue activating peptide III CXC chemokine ligand (CXCL)-1, 2, 3, 4, 5, 6, 7, 8, 12 and 16 Macrophage inflammatory protein 1α Neutrophil-activating peptide 2 Platelet factor 4 Regulated upon activation, normal T cell expressed and presumably secreted (RANTES) β-Thromboglobulin
Coagulation factors	Factor V Factor VII Factor XI Factor XIII Kininogens Plasminogen Protein S
Growth factors	Angiopoietin-1 and 2 Basic fibroblast growth factor Endothelial cell growth factor Epidermal growth factor Hepatocyte growth factor Insulin-like growth factor 1 Interleukin-2, 3, 4, 6, 7, and 8 Interleukin-β Platelet-derived growth factor Transforming growth factor β Vascular endothelial growth factor A & C
Immunoglobulins	Immunoglobulin A (IgA) Immunoglobulin E (IgE) Immunoglobulin G (IgG) Immunoglobulin M (IgM)
Protease inhibitors	C1-inhibitor Plasminogen activator inhibitor-1 Platelet inhibitor of factor XIα Platelet-derived collagenase inhibitor Protease nexin-II/amyloid β-protein precursor Tissue factor pathway inhibitor α-1-proteinase inhibitor α2-antiplasmin α2-antitrypsin α2-macroglobulin
Proteoglycans	Histidine-rich glycoprotein Neutrophil-activating peptide 2 Platelet basic protein Serglycin
Other	Albumin Glycoprotein Iα/Multimerin