Table 1.
Perioperative patient characteristics, Bold values indicate p-values < 0.05 and were considered statistically significant. Continuous values are presented as median and inter-quartile-range (IQR); categorical values are given as number (n; %) BMI: Body-Mass-Index; PSA preop: preoperative Prostate-specific Antigen level; LN: Lymphnode.
| Unmatched Cohort | Matched Cohort | |||||
|---|---|---|---|---|---|---|
| cM1-Oligo | cM0 | p | cM1-Oligo | cM0 | p | |
| No. of patients | 84 | 1184 | 79 | 332 | ||
| Age, years (median, IQR) # | 66 (59, 73) | 69 (66, 77) | 0.039 | 66 (60, 72) | 68 (60, 73) | 0.672 |
| BMI kg/m2 (median, IQR) # | 25.7 (24.0, 27.8) | 26.1 (24.3, 28.7) | 0.154 | 25.7 (24.0, 28) | 26.2 (24.3, 29.1) | 0.158 |
| PSA preop. ng/mL (median, IQR) | 25.2 (6.5, 63.3) | 8.3 (5.9, 13.6) | <0.001 | 21.1 (6.4, 51.0) | 10.9 (6.8, 20.2) | 0.024 |
| Prostate volume mL (median, IQR) | 47 (40, 58) | 52 (41, 66) | 0.007 | 47.5 (39.8, 58.0) | 53.5 (43.0, 67.0) | 0.002 |
| Gleason score (n (%)) | ||||||
| 6 | 0 (0.0) | 137 (11.5) | <0.001 | 0 (11.1) | 15 (4.5) | <0.001 |
| 7a | 3 (3.6) | 445 (37.6) | 3 (3.8) | 63 (19.0) | ||
| 7b | 10 (11.9) | 270 (22.8) | 9 (11.4) | 82 (24.7) | ||
| 8 | 18 (21.4) | 139 (11.8) | 17 (21.5) | 54 (16.3) | ||
| 9 | 46 (54.8) | 180 (15.2) | 42 (53.2) | 105 (31.6) | ||
| 10 | 7 (8.3) | 13 (1.1) | 8 (10.2) | 13 (3.9) | ||
| pT stage (n (%)) # | ||||||
| pT2a | 0 (0.0) | 62 (5.3) | 0.001 | 0 (0.0) | 0 (0.0) | 0.221 |
| pT2b | 0 (0.0) | 24 (2.0) | 0 (0.0) | 0 (0.0) | ||
| pT2c | 10 (11.9) | 616 (52.1) | 10 (12.7) | 60 (18.1) | ||
| pT3a | 15 (17.9) | 265 (22.4) | 15 (19.0) | 88 (26.5) | ||
| pT3b | 54 (64.3) | 211 (17.8) | 52 (65.8) | 178 (53.6) | ||
| pT4 | 5 (6.0) | 5 (0.4) | 2 (2.5) | 6 (1.8) | ||
| Nerve sparing (n (%)) | 14 (16.7) | 859 (72.6) | <0.001 | 13 (16.5) | 183 (55.1) | <0.001 |
| Robot-assisted RP (n (%)) | 10 (11.9) | 458 (38.7) | <0.001 | 10 (12.7) | 116 (34.9) | <0.001 |
| Positive surgical margin (n (%)) | 64 (76.2) | 322 (27.2) | <0.001 | 59 (74.7) | 165 (49.7) | <0.001 |
| Lymph node involvement (n (%)) | 46 (54.8) | 343 (29.0) | <0.001 | 41 (51.9) | 112 (33.7) | 0.003 |
| LN removed (median, IQR) | 10 (6, 13) | 11 (6, 18) | 0.124 | |||
| positive LN (median, IQR) | 1 (0, 3) | 1 (0, 1) | 0.059 | |||
| PSA postop. ng/mL (median, IQR) | 9.5 (2.0, 70.3) | 0.0 (0.0, 0.0) | <0.001 | |||
# matched variables.