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. 2021 Nov 15;13(22):5710. doi: 10.3390/cancers13225710

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CFTR inhibits CRC metastasis in vitro and in vivo. (A,B) Silencing CFTR expression by small interfering RNAs (siRNAs) promoted migration and invasion in Caco2 (A) and SW480 (B) cells. (C,D) Overexpression of CFTR inhibited migration and invasion in HCT116 (C) and HCT15 (D) cells. (E) Bioluminescent images and radiance values of mice (n = 8) injected with SW480 cells infected with lentiviral short hairpin RNA against CFTR (LV-shCFTR) or negative control (LV-shNC). (F) Representative H&E staining images of lung tissue sections from the indicated groups. Scale bars represent 500 μm. * p < 0.05, ** p < 0.01 by the Student’s t-test.