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. 2021 Nov 13;13(22):5681. doi: 10.3390/cancers13225681

Figure 4.

Figure 4

FGFR1–4 genetic alteration in cancer. Genetic alterations by cancer type and mutations of FGFR1 (A), FGFR2 (B), FGFR3 (C) and FGFR4 (D) were found in 662 (~6%), 360 (~3%), 351 (~3%) and 285 (~3%) patients, respectively out of 10,953 in total using cBioPortal. Mutation diagram circles and histograms are coloured with respect to the corresponding mutation types: Green = gene mutations; purple = structural variants; blue = deep deletions; grey = multiple alterations; red = gene amplifications. The lollipop diagrams of each FGF receptor (FGFR1–4), below each histogram, represent the mutation types in relation to the gene location (i.e., missense, truncating, in-frame, splice, SV/fusion). In the case of different mutation types at a single position, the colour of the circle is determined with respect to the most frequent mutation type.