Table 5.
Univariate and multivariate analyses of prognostic factors for OS in patients with CRC undergoing a curative resection.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p Value | HR | 95% CI | p Value | |
| Age (≥85/<85) | 2.34 | 1.940–2.822 | <0.001 | 2.046 | 1.673–2.502 | <0.001 |
| Sex (male/female) | 1.271 | 1.078–1.499 | 0.004 | 1.332 | 1.118–1.587 | 0.001 |
| BMI (<22/≥22) | 1.485 | 1.261–1.749 | <0.001 | 1.236 | 1.026–1.489 | 0.026 |
| CCI scores | ||||||
| 1–4 | 1 | 1 | ||||
| ≥5 | 2.517 | 2.055–3.084 | <0.001 | 2.081 | 1.658–2.612 | <0.001 |
| Albumin (<3.5/≥3.5) | 2.237 | 1.875–2.668 | <0.001 | 1.275 | 1.009–1.611 | 0.042 |
| WBC count (≥1000) | 1.495 | 1.208–1.849 | <0.001 | 1.005 | 0.784–1.287 | 0.971 |
| Hb (<10) | 1.331 | 1.113–1.593 | 0.002 | 0.887 | 0.724–1.086 | 0.246 |
| CEA (≥5) | 1.461 | 1.237–1.724 | <0.001 | 1.162 | 0.969–1.395 | 0.105 |
| PNI (<48) | 1.938 | 1.631–2.302 | <0.001 | 1.145 | 0.889–1.474 | 0.295 |
| NLR (≥2.91) | 1.688 | 1.429–1.995 | <0.001 | 1.208 | 0.989–1.476 | 0.064 |
| GNRI (<98) | 2.115 | 1.796–2.490 | <0.001 | 1.329 | 1.026–1.722 | 0.031 |
| Tumor location | ||||||
| Left colon/right colon | 0.804 | 0.707–1.055 | 0.152 | |||
| Rectum/right colon | 0.971 | 0.792–1.189 | 0.773 | |||
| Tumor invasion | ||||||
| T1 | 1 | 1 | ||||
| T2 | 0.929 | 0.612–1.412 | 0.73 | 0.924 | 0.598–1.428 | 0.723 |
| T3 | 1.221 | 0.864–1.726 | 0.258 | 0.904 | 0.621–1.316 | 0.904 |
| T4 | 2.453 | 1.675–3.592 | <0.001 | 1.473 | 0.959–2.263 | 0.077 |
| Lymph node metastasis | ||||||
| N0 | 1 | 1 | ||||
| N1 | 1.264 | 1.048–1.524 | 0.014 | 1.27 | 1.036–1.556 | 0.021 |
| N2 | 2.053 | 1.649–2.557 | <0.001 | 2.061 | 1.623–2.618 | <0.001 |
| Stage | ||||||
| Stage I | 1 | |||||
| Stage II | 1.178 | 0.908–1.529 | 0.218 | |||
| Stage III | 1.685 | 1.303–2.177 | <0.001 | |||
| Histological grade | ||||||
| Well/moderately differentiated | 1 | 1 | ||||
| Poorly differentiated | 1.503 | 1.171–1.929 | 0.001 | 1.127 | 0.812–1.564 | 0.475 |
| Histological type | ||||||
| Adenocarcinoma | 1 | 1 | ||||
| Poor features * | 1.537 | 1.137–2.077 | 0.005 | 1.127 | 0.766–1.656 | 0.544 |
| Operative type (emergency) | 1.951 | 1.168–3.259 | 0.011 | 1.003 | 0.539–1.868 | 0.991 |
| Operative method (open) | 1.093 | 0.909–1.315 | 0.344 | |||
* Poor features: mucinous/signet ring cell/undifferentiated adenocarcinoma.