Table 6.

Univariate and multivariate analysis of prognostic factors for DFS in patients with CRC undergoing a curative resection.

Variables	Univariate			Multivariate
	HR	95% CI	p Value	HR	95% CI	p Value
Age (≥85/<85)	2.145	1.783–2.579	<0.001	1.9	1.560–2.316	<0.001
Sex (male/female)	1.279	1.090–1.502	0.003	1.341	1.130–1.591	0.001
BMI (<22/≥22)	1.394	1.188–1.636	<0.001	1.186	0.988–1.423	0.067
CCI scores
1–4	1			1
≥5	2.262	1.849–2.768	<0.001	1.938	1.547–2.429	<0.001
Albumin (<3.5/≥3.5)	2.091	1.759–2.486	<0.001	1.201	0.954–1.512	0.118
WBC count (≥1000)	1.427	1.157–1.759	0.001	0.937	0.734–1.195	0.599
Hb (<10)	1.309	1.099–1.559	0.002	0.88	0.722–1.073	0.207
CEA (≥5)	1.554	1.323–1.827	<0.001	1.259	1.054–1.503	0.011
PNI (<48)	1.866	1.578–2.207	<0.001	1.162	0.911–1.484	0.227
NLR (≥2.91)	1.633	1.387–1.922	<0.001	1.194	0.982–1.452	0.075
GNRI (<98)	1.985	1.694–2.327	<0.001	1.312	1.021–1.685	0.034
Tumor location
Left colon/right colon	0.885	0.728–1.076	0.222
Rectum/right colon	0.998	0.819–1.217	0.987
Tumor invasion
T1	1			1
T2	0.951	0.627–1.443	0.814	0.94	0.609–1.450	0.78
T3	1.364	0.966–1.927	0.078	1.01	0.695–1.469	0.957
T4	2.734	1.871–3.994	<0.001	1.675	1.096–2.560	0.017
Lymph node metastasis
N0	1			1
N1	1.337	1.115–1.603	0.002	1.345	1.106–1.637	0.003
N2	2.222	1.792–2.756	<0.001	2.212	1.748–2.799	<0.001
Stage
Stage I	1
Stage II	1.264	0.977–1.636	0.075
Stage III	1.883	1.461–2.426	<0.001
Histological grade
Well/moderately differentiated	1
Poorly differentiated	1.414	1.105–1.811	0.006	1.018	0.739–1.402	0.913
Histological type
Adenocarcinoma	1
Poor features *	1.407	1.042–1.901	0.026	1.057	0.725–1.541	0.773
Operative type (emergency)	2.074	1.262–3.408	0.004	1.035	0.572–1.874	0.909
Operative method (open)	1.1	0.919–1.315	0.298

* Poor features: mucinous/signet ring cell/undifferentiated adenocarcinoma.