Table 1.
HSP70 Protein | ATPase | Protein Folding | Facilitates Protein Degradation Through: | Protein Localization Control | Lysosome Protection | Immune Function Regulation | Cell Cycle, Survival and Death |
---|---|---|---|---|---|---|---|
Hsp70 | X | X | UPS | X | X | X | |
Hsc70 | X | X | CMA, EmiA | Cytoplasm vs. lysosome or nucleus | X | X | |
Grp78 | X | X | UPR, UPS, macroautophagy | Retrograde ER transport | X | X | |
Mortalin | X | X | UPRmt | Cytoplasm vs. mitochondria or nucleus | X | X |