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. 2021 Nov 3;10(11):2996. doi: 10.3390/cells10112996

Table 1.

Comparison of HSP70 protein functions.

HSP70 Protein ATPase Protein Folding Facilitates Protein Degradation Through: Protein Localization Control Lysosome Protection Immune Function Regulation Cell Cycle, Survival and Death
Hsp70 X X UPS X X X
Hsc70 X X CMA, EmiA Cytoplasm vs. lysosome or nucleus X X
Grp78 X X UPR, UPS, macroautophagy Retrograde ER transport X X
Mortalin X X UPRmt Cytoplasm vs. mitochondria or nucleus X X