Figure 3.

Frequency of common somatic mutations in melanomas are estimated based on Vanni et al.’s analysis of the frequency of somatic mutations from different studies [33]. Fusion gene frequencies were obtained from non-TCGA database, and the frequency varies among different studies. Arrows indicate the presence of FDA-approved inhibitors in cancers harboring mutations for the specific gene in non-melanoma cancers. Orange asterisks indicate the presence of ongoing trials in melanoma patients with mutation-specific alterations or melanoma patients receiving targeted therapy for the specific mutant gene. TCGA: the cancer genome atlas; FDA: food and drug administration.