Table 2.

Phenotype of selected genetic mouse models of IBD. n.d.: not determined.

Gene	Type of Mutation	Model	Disease	Therapy (Free GCs)	Reference
GR	myeloid cell-specific deletion	DSS-colitis	aggravated	n.d.	[83]
GR	IEC-specific deletion, inducible	DSS-colitis	aggravated	n.d.	[7]
GR	Treg cell-specific deletion	T-cell transfer colitis	aggravated	n.d.	[84]
GR	impaired dimerization, ubiquitous	TNFα-induced intestinal inflammation	aggravated	abrogated	[27]
GILZ	neutrophil-specific deletion	DNBS-colitis	aggravated	n.d.	[90]
GILZ	T cell-specific deletion	DNBS-colitis	aggravated	n.d.	[91]