Table 4.

Phenotype of selected genetic mouse models of RA. AnX1: Annexin A1. n.d.: not determined.

Gene	Type of Mutation	Model	Disease	Therapy (Free GCs)	Reference
GR	T cell-specific deletion	AIA	unaltered	abrogated	[141]
GR	myeloid cell-specific deletion	AIA	unaltered	unaltered	[141]
GR	B cell-specific deletion	AIA	unaltered	unaltered	[141]
GR	impaired dimerization, ubiquitous	AIA	unaltered	abrogated	[141]
GR	deletion in immune cells	STIA	unaltered	unaltered	[143]
GR	deletion in stromal cells	STIA	unaltered	abrogated	[143]
GR	FLS-specific deletion, inducible	STIA	unaltered	partially abrogated	[143]
11β-HSD1	ubiquitous deletion	STIA	aggravated	partially abrogated	[144,147]
AnX1	ubiquitous deletion	STIA	unaltered	abrogated	[156]
GILZ	ubiquitous deletion	CIA	unaltered	unaltered	[162]
DUSP1	ubiquitous deletion	CIA	aggravated	n.d.	[163]