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. 2021 Oct 20;10(11):2813. doi: 10.3390/cells10112813

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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AGA-luciferase minigene splicing assays in patient fibroblasts (a–c) Patient fibroblasts were transfected with the AGA-luciferase minigene construct and treated with (a) 7.5 mM of substances or (b) increasing amounts of caffeine or (c) theophylline for 24 h. Relative luciferase activity of the untreated samples was set as 1. Bars represent the mean ± SD of at least five independent experiments, statistics with one-way ANOVA against the untreated samples. Values of p < 0.01 were considered very significant (**) and p < 0.001 extremely significant (***).