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. 2021 Oct 20;10(11):2813. doi: 10.3390/cells10112813

Figure 8.

Figure 8

Effect of xanthine derivatives on the AGA activity and AGA mRNA level in AGU fibroblasts. Patient fibroblasts were treated for 48 h with 7.5 mM caffeine (a) or other methylxanthines (b), and the AGA activity was measured; n = 4, graphs show the mean ± SD. Statistical analysis by one-way ANOVA. (c) Patient and control fibroblasts were treated with 7.5 mM caffeine for 24 h. AGA transcript level was measured with qPCR using primers for exons 2 and 3, n = 6, two-way ANOVA. Values of p < 0.05 were considered significant (*)and p < 0.001 extremely significant (***).