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. 2021 Nov 4;10(11):3017. doi: 10.3390/cells10113017

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Treatment strategies for RA therapy. (A) New approaches in RA treatment. (1) TNF-inhibitors, (2) co-stimulation blockers (Abatacept), (3) Janus-Activated-Kinase (JAK) inhibitors (Tofacitinib + Baricitinib), (4) CD20 (Rituximab, Ofatumumab) and CD22 (Epratuzumab) targeting on B-cell surfaces and plasma cell targeting therapies (ATG), (5) IL-1 and IL-6 targeting mAbs (Anakinra and Tocilizumab), (6) intraarticular administration of mesenchymal stem cells. (B) Common standard treatments for RA patients (NSAIDs, GCs, biological response modifiers, and DMARDs).