Figure S1. Knockdown of LATS1 and LATS2 is required to activate YAP/TAZ and to induce a proliferative-to-invasive phenotype switch.

(A, B) Quantitative RT-PCR analysis to assess knockdown efficiencies as well as the expression of YAP/TAZ target genes (CYR61, CTGF, SERPINE1, and ANKRD1), melanocyte (MITF and MLANA) and mesenchymal (FN1) marker genes in M000921 (a) or M010817 cells (b) transfected with siRNAs targeting LATS1, LATS2, or both. Mean + SEM of n = 3 replicates are shown *P < 0.05; **P < 0.01; ratio-paired t test.