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. 2021 Oct 28;10(11):2939. doi: 10.3390/cells10112939

Figure 7.

Figure 7

Cav-1 downregulation results in accelerated SIPS. (A) Representative photos of early passage WJ-MSCs (early), early passage WJ-MSCs treated with siRNA against caveolin-1 (siCav-1), early passage cells after being subjected to stress induced premature senescence (SIPS) at passage 1 (SIPS p1) and early passage WJ-MSCs treated with siRNA against caveolin-1 after being subjected to stress induced premature senescence (SIPS) at passage 1 (siCav-1+SIPS p1), stained with SA-β-gal staining solution. (B) Graph showing the percentage of SA-β-gal positive cells in early, SIPS p1, siCav-1 and siCav-1+SIPS p1 WJ-MSCs. p values shown are the means ± S.E. * p < 0.05 vs. early passage or otherwise indicated. p values calculated using the Student t-test.