Table 2.
Summary of the molecular players impaired in congenital lung diseases.
| Congenital Lung Disease | Altered Epithelial Signaling/Expression |
Altered Mesenchymal Signaling/Expression |
References |
|---|---|---|---|
| CPAM | Integrin | Integrin | [117] |
| E-cadherin | - | [117] | |
| - | PDGF-BB | [118] | |
| GDNF | - | [119] | |
| - | FABP-7 | [120] | |
| CC10 | - | [115] | |
| KRAS; PI3K-AKT-mTOR | - | [121] | |
| VEGFR2 | - | [122] | |
| - | HOXB5 | [123,125] | |
| TTF1/Nkx2.1 | - | [124,125,140] | |
| fgf9 | - | [125,129] | |
| - | fgf7 | [125,127,130] | |
| - | fgf10 | [126,128,131,132,134,135] | |
| fgfr2 | - | [135] | |
| DICER | - | [131] | |
| yy1 | - | [132,133] | |
| shh | - | [24,132,134] | |
| cdc42 | - | [134] | |
| - | ptc1 | [134] | |
| foxa1; foxa2 | - | [24] | |
| fzd2 | - | [135] | |
| RhoA | - | [135] | |
| hdac1; hdac2 | - | [136] | |
| bmpr1a | - | [137] | |
| Mycn | - | [138] | |
| Yap | - | [59] | |
| SOX2 | - | [55,139,140] | |
| SOX9 | - | [54] | |
| Notch | - | [141] | |
| - | Elastin | [142] | |
| CDH | - | RALDH2 | [187] |
| RAR | RAR | [186] | |
| - | STRA6 | [174,187] | |
| Midkine | Midkine | [186] | |
| FGF signaling | - | - | |
| - | FGF10 | [189] | |
| FGF2 | FGF2 | [186] | |
| - | FGF7 | [189,190] | |
| FGF9 | - | [186] | |
| - | FGF18 | [191] | |
| FGFR2 | FGFR2 | [186] | |
| FGFR3 | FGFR3 | [186] | |
| BMP signaling | - | - | |
| BMP4 | - | [186] | |
| BMP7 | - | [186] | |
| BMPR2 | - | [186] | |
| WNT signaling | - | - | |
| - | WNT2 | [186] | |
| WNT5A | WNT5A | [186] | |
| WNT7B | - | [186] | |
| - | GATA6 | [198] | |
| - | GATA4 | [192,193] | |
| - | NR2F2 | [194] | |
| ZFPM2 | - | [195] | |
| - | WT1 | [196] | |
| - | MYRF | [199] | |
| - | GLI | [200] | |
| - | KIF7 | [201] | |
| - | PBX1 | [202] | |
| - | SLIT3 | [174,179,203] | |
| ROBO1 | ROBO1 | [174,179] | |
| NDST1 | - | [174,179] | |
| FREM1 | - | [174,179] | |
| - | FRAS1 | [174,179] | |
| - | FREM2 | [174] | |
| miR-200b | miR-200b | [207] |