Table 3.
T-cell immune responses among healthy ChAdOx1 nCoV-19-vaccinated participants
| Total number of samples tested | Wild-type SARS-CoV-2 spike peptide pool | Delta (B.1.617.2) SARS-CoV-2 spike peptide pool | p value | ||
|---|---|---|---|---|---|
| Cytokines secreted by stimulated PBMCs (pg/mL) | |||||
| IFNγ | 48 | 22 947 (23 159) | 28 316 (28 955) | 0·39 | |
| IL-2 | 48 | 2049 (3524) | 2053 (3731) | 0·79 | |
| TNFα | 48 | 169 (247) | 204 (330) | 0·83 | |
| Intracellular cytokine staining (%)* | |||||
| CD4 T cells | |||||
| IFNγ | 41 | 0·22% (0·35) | 0·21% (0·25) | 0·24 | |
| IL-2 | 41 | 0·24% (0·32) | 0·24% (0·35) | 0·54 | |
| TNFα | 41 | 0·42% (0·79) | 0·29% (0·38) | 0·43 | |
| CD8 T cells | |||||
| Granzyme | 41 | 1·5% (2·27) | 0·97% (1·55) | 0·16 | |
| IFNγ | 41 | 0·16% (0·24) | 0·11% (0·18) | 0·14 | |
| Perforin | 41 | 1·82% (2·91) | 1·34% (2·27) | 0·26 | |
| Activation-induced markers (%)* | |||||
| CD4+CD137+OX-40+ | 38 | 0·60% (0·74) | 0·66% (1·01) | 0·62 | |
| CD8+CD137+CD69+ | 38 | 0·25% (0·42) | 0·29% (0·43) | 0·26 | |
Data are mean (SD). PBMCs=peripheral blood mononuclear cells. IFN=interferon. IL=interleukin. TNF=tumour necrosis factor.
*
Data are the proportions of cells expressing the indicated molecules.