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. 2021 Nov 25;30(10):25148–25169. doi: 10.1007/s11356-021-17567-3

Table 1.

Fossil-based active ingredients used in cosmetic formulations associated with health risk

Active ingredient of concern (Fossil fuel-based) Uses Risk Reference
Sodium lauryl sulfate (SLS) Ability to foam, rinse off, or suspend certain types of ingredients, surfactants, emulsifying agents in household cleaners Remove moisture from the skin, eyes, skin, and lungs irritant, the possible presence of human carcinogen 1,4 dioxane (Black et al. 2001; Heetfeld et al. 2020)
Synthetic colors—petroleum-based ingredients Use in pharmaceuticals and cosmetics, artificial dyes Contribute to cancer, allergies, hyperactivity in children, and other health issues (Kim et al. 2021)
Phthalates: diethyl, dibutyl phthalate (DBP) Give products a silky feel, allow the fragrance to last longer, aid lotions in penetrating and softening skin DNA damage in sperm, which can contribute to infertility and miscarriage (Koniecki et al. 2011)
Aluminum Antiperspirants Linked to breast cancer, Alzheimer’s disease, and osteoporosis (SCCS and Rousselle 2015; Kalogria et al. 2019)
Microbeads Chewing gum, toothpaste, facial cleansers, and synthetic textiles Contaminate our environment, water, and food supply (Lochhead 2017; Hunt et al. 2020)
methyl-, butyl-, and propyl-paraben Antimicrobial and preservative agents, cost-effective, and easy to use Endocrine disruption, reduced fertility, and cancer risk (Evans et al. 2016)
Paraffin wax Easily spreadable, soothe achy joints, used in moisturizing products, skin hydration Carcinogenic, inhalation of the particle leads to allergy and asthma (Gomes et al. 2020a)
Mineral oil Moisturize skin, keep skin hydrated, nonallergic Skin irritant such as rash or burning, inhalation to lungs cause breath shortness/coughing (Chuberre et al. 2019)
Toluene listed as methacide, methylbenzene, phenylmethane, and toluol Used in nail polish and hair dyes Most toxic ingredients, developmental damage to the fetus, and blood cancer (Al-Hajri and Del Bigio 2010; Verma 2012)
Triclosan: high-concern ingredient Antibacterial soaps, deodorants and toothpastes, anti-gingivitis and anti-plaque agent Hinder muscle function, endocrine disruption, create drug-resistant germs, and colon tumorigenesis (Dhillon et al. 2015; Lee et al. 2019)
Anything with PEG (polyethylene glycol) Used as cosmetic cream bases, moisture-carriers, thickeners, softeners, penetration enhancers, and surfactants Often contaminated with ethylene oxide or 1,4-dioxane which are carcinogenic, irritation, and system toxicity (Fruijtier-Pölloth 2005)
Anything with DEA (diethanolamine) or TEA (triethanolamine)

DEA-emulsifier in shampoos, cleaners, and detergents

TEA-fragrance, pH adjuster, and emulsifying agent

Accumulates in liver and kidney, reduce sperm ability to swim, impaired memory, and brain development in offsprings (Panchal and Verma 2013)(Gamer et al. 2008)
EDTA (ethylenediaminetetraacetic acid) Stabilizer, preservative, improve the foaming abilities of cleansers, soaps, and body washes Reproductive toxicity and irritation, weakly mutagenic (Lanigan et al. 2002a)
Any word with propyl—isopropyl alcohol, propylene glycol, propyl alcohol, and cocamidopropyl betaine Surfactants, use rinse-off cosmetic products as a foam booster, antistatic agents, and hair-conditioning agents Dermal irritants, allergies, rosacea, and eczema (Burnett et al. 2012)
Formaldehyde-releasing preservatives These preservatives are present in a wide range of cosmetics, as well as in cleaning products such as toilet bowl cleaners Formaldehyde-releasing preservatives continuously release small amounts of formaldehyde, a known human carcinogen (Moennich et al. 2009; Lv et al. 2015)
Coal tar dyes: listed as p-phenylenediamine or colors titled “CI” and followed by a 5-digit number Color additive in lipsticks, used in many hair dyes These dyes are mixtures of petrochemicals and linked to cancer in humans, brain damage (FDA 2019)
BHA (butylated hydroxyanisole) and BHT (butylated hydroxytoluene) Synthetic antioxidants, preservatives, stabilizer, and most common in lipsticks and moisturizing creams Disrupt the endocrine system (Jayalakshmi and Sharma 1986; Lanigan et al. 2002b)