Table 4.
Chronic LPS exposure decreases cardiac function as determined by echocardiography
| D0 | LPS | MI | Lps + MI | LPS + MI + MHCi | LPS + MI + IgG | |
|---|---|---|---|---|---|---|
| n (male/female) | 18 (9/9) | 20 (10/10) | 18 (9/9) | 12 (6/6) | 5 (2/3) | 7 (4/3) |
| EDD, mm | 3.56 ± 0.09 | 3.69 ± 0.06 | 4.29 ± 0.12a,b | 4.48 ± 0.07a,b | 4.63 ± 0.23a,b | 4.38 ± 0.12a,b |
| ESD, mm | 2.28 ± 0.07 | 2.57 ± 0.07a | 3.90 ± 0.15a,b | 4.19 ± 0.07a,b | 4.23 ± 0.23a,b | 3.96 ± 0.11a,b |
| FS, % | 36 ± 1 | 31 ± 1a | 10 ± 2a,b | 6 ± 1a,b | 9 ± 2a,b | 9 ± 1a,b |
| EDV, µL | 61 ± 3 | 59 ± 3 | 77 ± 5a,b | 78 ± 3a,b | 83 ± 9a,b | 84 ± 8a,b |
| ESV, µL | 20 ± 1 | 25 ± 1 | 66 ± 5a,b | 66 ± 3a,b | 70 ± 8a,b | 67 ± 6a,b |
| EF, % | 65 ± 1 | 57 ± 1a | 16 ± 1a,b | 16 ± 1a,b | 17 ± 3a,b | 20 ± 2a,b |
| Wall thickness | ||||||
| Diastole | 0.84 ± 0.02 | 0.79 ± 0.01 | 0.79 ± 0.04 | 0.51 ± 0.03a,b,c | 0.59 ± 0.06a,b,c | 0.62 ± 0.04a,b,c |
| Systole | 1.25 ± 0.03 | 1.14 ± 0.02 | 0.90 ± 0.07a,b | 0.58 ± 0.04a,b,c | 0.74 ± 0.11a,b | 0.68 ± 0.04a,b,c |
| Infarct size, % | NA | NA | 58 ± 3 | 58 ± 3 | 58 ± 2 | 55 ± 1 |
Values are means ± SE. EDD, end-diastolic dimension; EDV, end-diastolic volume; EF, ejection fraction; ESD, end-systolic dimension; ESV, end-systolic volume; FS, fractional shortening; LPS, lipopolysaccharides; MI, myocardial infarction. aP < 0.05 vs. D0; bP < 0.05 vs. LPS; cP < 0.05 vs. MI.