Table 2.
Laboratory characteristics of girls in CPP and IPT groups (classified by the initial GnRH test findings)
| CPP (n = 32) |
IPT (n = 28) |
P value | |
|---|---|---|---|
| GnRH test | |||
| Basal FSH b (IU/L) | 4.3 (2.8–5.1) | 1.5 (0.6–1.8) | <0.001** |
| Peak FSH (IU/L) | 10.7 (8.6–11.2) | 8.6 (5.7–11.7) | 0.025* |
| Basal LH c (IU/L) | 1.3 (0.7–2.3) | 0.1 (0.1–0.1) | <0.001** |
| Peak LH (IU/L) | 10.3 (7.5–17.9) | 2.5 (2.2–3.2) | |
| Basal estradiol (pmol/L) | 102 (37–152) | 37 (37–37) | <0.001** |
| Triptorelin test | |||
| Basal FSH (IU/L) | 4.4 (3.0–5.7) | 1.4 (0.5–1.9) | <0.001** |
| Peak FSH (IU/L) | 17.1 (14.0–19.9) | 13.3 (8.8–17.4) | 0.006** |
| Basal LH (IU/L) | 1.7 (0.6–2.7) | 0.1 (0.1–0.1) | <0.001** |
| 30 min LH (IU/L) | 10.3 (4.9–19.8) | 1.4 (0.8–2.2) | <0.001** |
| 60 min LH (IU/L) | 12.4 (6.1–19.7) | 1.7 (0.9–2.3) | <0.001** |
| 90 min LH (IU/L) | 12.9 (6.7–18.4) | 1.8 (1.0–2.6) | <0.001** |
| 120 min LH (IU/L) | 12.7 (8.0–18.1) | 2.0 (1.1–2.7) | <0.001** |
| 180 min LH (IU/L) | 15.8 (11.0–24.6) | 2.1 (1.2–2.7) | <0.001** |
| 24 h LH (IU/L) | 8.8 (3.7–13.8) | 0.8 (0.6–1.2) | <0.001** |
| Peak LH (IU/L) | 18.5 (12.9–24.6) | 2.1 (1.3–3.0) | <0.001** |
| Basal estradiol (pmol/L) | 66 (37–163) | 37 (37–37) | <0.001** |
| 24 h estradiol (pmol/L) | 735 (396–1041) | 157 (56–378) | <0.001** |
CPP central precocious puberty, IPT isolated premature thelarche, GnRH gonadotropin-releasing hormone, FSH follicle-stimulating hormone, LH luteinizing hormone. Results are presented as median (25th–75th percentile); statistically significant differences are marked with * for p < 0.05 and ** for p < 0.01.