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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Immunol Rev. 2021 Aug 8;304(1):30–50. doi: 10.1111/imr.13018

Figure 4. Classic examples of AS in the immune response.

Figure 4.

A. Upon T cell activation, GSK3 inactivation leads to subsequent PSF activity to then influence CD45RABC splicing to CD45RO along with hnRNPL/LL and CTCF. B. Upon T cell activation, the activation of JNK kinase signaling regulates CELF2 activity to influence the splicing of LEF1 and MKK7. A feed-forward loop is established as MKK7 ΔE2 phosphorylates JNK to then further regulate CELF2 activity. C. LPS incudes macrophage activation through TLR4 signaling. TLR4 recruits MyD88 which further recruits IRAK4 (only the long form of MyD88) and IRAK1. IRAK1 is phosphorylated by IRAK4, when co-recruited, to promote NFkB signaling.