Table 1.
Evolutionary Assignment of CASP13 Targets among Existing Folds
| Target EU | Taxonomy | Class | ECOD Architecture | ECOD Assignment (X-group/H-group) | Level |
|---|---|---|---|---|---|
| T1024-D1 | Bacteria | TBM-easy | alpha complex | Major facilitator superfamily (MFS) transporter | H-group |
| T1024-D2 | Bacteria | TBM-easy | alpha complex | Major facilitator superfamily (MFS) transporter | H-group |
| T1025 | Bacteria | TBM-easy | a/b 3-layered sandwich | Rossmann-related | Family |
| T1026 | Virus | TBM-hard | beta sandwiches | Nucleoplasmin-like/VP (viral coat and capsid proteins) | H-group |
| T1027 | Eukaryota | FM | alpha arrays | na | New |
| T1028 | Bacteria | TBM-easy | a+b complex | C-type lectin-like | Family |
| T1029 | Bacteria | FM | a+b two layers | Type III secretory system chaperone-like | New |
| T1030-D1 | Bacteria | TBM-hard | alpha bundles | Bacterial immunoglobulin/albumin-binding domains | H-group |
| T1030-D2 | Bacteria | TBM-hard | alpha bundles | Bacterial immunoglobulin/albumin-binding domains | H-group |
| T1031 | Virus | FM | a+b two layers | dsRBD-like | X-group |
| T1032 | Eukaryota | TBM-hard | a+b duplicates/obligate | Smc hinge domain | Family |
| T1033 | Virus | FM | alpha arrays | Enhancer of polycomb-like protein 1 (Epl1) N-domain | X-group |
| T1034 | Eukaryota | TBM-easy | beta complex | Hedgehog/intein | Family |
| T1035 | Virus | FM/TBM | alpha arrays | na | New |
| beta complex | Viral glycoprotein ectodomain-like | ||||
| T1036s1 | Virus | TBM-easy | beta barrels | first barrel domain in viral glycoproteins | Family |
| beta barrels | Glycoprot B PH2 | ||||
| T1037 | Virus | FM | a+b complex | na | New |
| T1038-D1 | Virus | FM | a+b complex | na | New |
| T1038-D2 | Virus | FM/TBM | beta sandwiches | Immunoglobulin-related | H-group |
| T1039 | Virus | FM | alpha bundles | Fatty acid responsive transcription factor FadR, C-domain | X-group |
| T1040 | Virus | FM | alpha arrays | na | New |
| T1041 | Virus | FM | alpha complex | RNAi polymerase helical domain | H-group |
| T1042 | Virus | FM | alpha arrays | na | New |
| T1043 | Virus | FM | beta barrels | cradle loop barrel | X-group |
| T1045s1 | Eukaryota | TBM-easy | a+b two layers | UBC-like | Family |
| T1045s2 | Eukaryota | TBM-hard | a/b 3-layered sandwich | HAD domain-related | H-group |
| T1046s1 | Virus | FM/TBM | alpha bundles | Sigma2 domain-like | X-group |
| T1046s2 | Virus | TBM-hard | a+b three layers | Sensor domain | H-group |
| T1047s1 | Bacteria | FM | beta barrels | secretin domain | H-group |
| T1047s2-D1 | Bacteria | FM/TBM | beta barrels | RIFT-related | H-group |
| T1047s2-D2 | Bacteria | TBM-hard | a+b two layers | Ring-building motif II in type III secretion system | H-group |
| T1047s2-D3 | Bacteria | FM/TBM | a+b complex | na | New |
| T1049 | Bacteria | FM | beta sandwiches | Immunoglobulin-like beta-sandwich | X-group |
| T1050-D1 | Bacteria | TBM-easy | beta duplicates/obligate | beta-propeller | Family |
| T1050-D2 | Bacteria | TBM-easy | beta duplicates/obligate | beta-propeller | Family |
| T1050-D3 | Bacteria | TBM-easy | beta sandwiches | Immunoglobulin-related | Family |
| T1052-D1 | Virus | TBM-easy | beta duplicates/obligate | Pectin lyase-like | Family |
| beta sandwiches | Domain in virus attachment proteins | ||||
| T1052-D2 | Virus | TBM-easy | a/b 3-layered sandwich | SGNH hydrolase | H-group |
| T1052-D3 | Virus | FM/TBM | beta barrels | RIFT-related | H-group |
| T1053-D1 | Bacteria | FM/TBM | a+b complex | Protein kinase/SAICAR synthase/ATP-grasp | H-group |
| T1053-D2 | Bacteria | FM/TBM | alpha bundles | Bromodomain-like | X-group |
| T1054 | Bacteria | TBM-hard | a+b two layers | amino-terminal domain of OmpATb | H-group |
| T1055 | Virus | FM/TBM | alpha arrays | Sec63 N-terminal subdomain-like | H-group |
| alpha array | LEM/SAP HeH motif | H-group | |||
| T1056 | Virus | TBM-hard | a+b complex | alpha/beta-Hammerhead/Barrel-sandwich hybrid | Family |
| T1057 | Bacteria | TBM-easy | a/b 3-layered sandwich | Rossmann-related | Family |
| T1058-D1 | Bacteria | FM/TBM | alpha bundles | Transmembrane heme-binding four-helical bundle | H-group |
| T1058-D2 | Bacteria | TBM-hard | a+b two layers | Cystatin/monellin | H-group |
| T1060s2 | Virus | TBM-hard | beta barrels | RIFT-related | H-group |
| beta barrels | RIFT-related | ||||
| T1060s3 | Virus | TBM-hard | beta sandwiches | N-terminal Ig-like domain in baseplate protein ORF48 | H-group |
| beta barrels | RIFT-related | ||||
| T1061-D1 | Virus | FM/TBM | a+b complex | N0 domain in phage tail proteins and secretins | H-group |
| beta barrels | RIFT-related | ||||
| a+b complex | C-terminal insertion domain in phage tail proteins | ||||
| T1061-D2 | Virus | FM | beta sandwiches | jelly-roll | X-group |
| T1061-D3 | Virus | TBM-easy | beta sandwiches | Immunoglobulin-related | H-group |
| T1064 | Virus | FM | beta sandwiches | Immunoglobulin-related | H-group |
| T1065s1 | Bacteria | TBM-hard | a+b two layers | RelE-like | H-group |
| T1065s2 | Bacteria | FM/TBM | a+b two layers | na | New |
| T1067 | Bacteria | TBM-hard | beta complex | L,D-transpeptidase catalytic domain-like | Family |
| T1068-D1 | Eukaryota | TBM-hard | alpha arrays | Thymine dioxygenase JBP1 DNA-binding domain | H-group |
| T1070-D1 | Virus | FM | beta duplicates/obligate | Phage tail fiber protein trimerization domain | H-group |
| T1070-D2 | Virus | TBM-easy | beta sandwiches | gp9 N-terminal domain-related | H-group |
| T1070-D3 | Virus | TBM-hard | beta sandwiches | Agglutinin HPA-like | H-group |
| T1070-D4 | Virus | TBM-easy | beta sandwiches | Agglutinin HPA-like | H-group |
| T1073 | Bacteria | TBM-easy | alpha arrays | HTH | H-group |
| T1074 | Bacteria | FM | beta barrels | Lipocalins/Streptavidin | X-group |
| T1076 | Bacteria | TBM-easy | a/b 3-layered sandwich | Thiamin diphosphate-binding fold (THDP-binding) | |
| a/b 3-layered sandwich | Rossmann-related | Family | |||
| a/b 3-layered sandwich | Thiamin diphosphate-binding fold (THDP-binding) | ||||
| T1078 | Eukaryota | TBM-hard | beta barrels | Allergen Alt a 1 | H-group |
| T1079 | Bacteria | TBM-hard | a+b complex | Lysozyme-like | Family |
| alpha arrays | PGBD-like | ||||
| beta complex | L,D-transpeptidase catalytic domain-like | ||||
| T1080 | Bacteria | FM/TBM | beta duplicates/obligate | Phage tail fiber protein trimerization domain | H-group |
| T1082 | Virus | FM/TBM | alpha arrays | PABC(PABP) domain | H-group |
| T1083 | Bacteria | TBM-hard | alpha duplicates/obligate | Ferritin/Heme oxygenase/4-helical cytokines | X-group |
| T1084 | Bacteria | TBM-hard | alpha duplicates/obligate | Ferritin/Heme oxygenase/4-helical cytokines | X-group |
| T1085-D1 | Bacteria | TBM-hard | alpha superhelices | ARM repeat | H-group |
| T1085-D2 | Bacteria | FM/TBM | alpha superhelices | ARM repeat | H-group |
| T1085-D3 | Bacteria | TBM-hard | alpha superhelices | ARM repeat | H-group |
| T1086-D1 | Bacteria | TBM-easy | alpha superhelices | ARM repeat | Family |
| T1086-D2 | Bacteria | TBM-hard | alpha superhelices | ARM repeat | H-group |
| T1087 | Bacteria | TBM-hard | alpha duplicates/obligate | Ferritin/Heme oxygenase/4-helical cytokines | X-group |
| T1089 | Bacteria | TBM-easy | beta duplicates/obligate | beta-propeller | Family |
| T1090 | Eukaryota | FM | beta complex | ETN0001 domain-like | H-group |
| T1091-D1 | Bacteria | TBM-easy | beta sandwiches | Immunoglobulin-related | H-group |
| T1091-D2 | Bacteria | TBM-easy | beta sandwiches | Immunoglobulin-related | H-group |
| T1091-D3 | Bacteria | TBM-easy | beta sandwiches | Immunoglobulin-related | Family |
| T1091-D4 | Bacteria | TBM-easy | beta sandwiches | Immunoglobulin-related | Family |
| T1092-D1 | Virus | TBM-hard | a+b complex | N-terminal domain in RNA-polymerase beta-prime subunit | H-group |
| T1092-D2 | Virus | TBM-easy | beta barrels | RIFT-related | Family |
| T1093-D1 | Virus | FM | a+b complex | 1st helical domain in RNA-polymerase beta-prime subunit | H-group |
| T1093-D2 | Virus | TBM-hard | a+b complex | 2nd helical domain in RNA-polymerase beta-prime subunit | |
| a+b two layers | MoeA-I/ODC-C/Reverse ferredoxin-like domain in RNA-pol | H-group | |||
| T1093-D3 | Virus | FM | a+b complex | alpha/beta-Hammerhead/Barrel-sandwich hybrid | H-group |
| T1094-D1 | Virus | TBM-hard | a+b complex | N-domain in beta subunit of DNA dependent RNA-pol | Family |
| T1094-D2 | Virus | FM | a+b complex | insert domain in beta subunit of DNA dependent RNA-pol | H-group |
| beta barrels | RIFT-related | ||||
| T1095 | Virus | TBM-hard | a+b complex | alpha/beta-Hammerhead/Barrel-sandwich hybrid | |
| a+b complex | alpha/beta-Hammerhead/Barrel-sandwich hybrid | ||||
| a+b complex | C-domain in beta subunit of DNA dependent RNA-pol | Family | |||
| T1096-D1 | Virus | FM | alpha complex | Sigma2 domain of RNA polymerase sigma factors | H-group |
| T1096-D2 | Virus | FM | alpha complex | na | New |
| T1099 | Virus | TBM-hard | alpha arrays | Hepatitis B viral capsid (hbcag) | Family |
| T1100-D1 | Archaea | TBM-hard | extended segments | NarQ transmembrane domain | H-group |
| alpha duplicates/obligate | HAMP domain | ||||
| T1100-D2 | Archaea | TBM-hard | a+b three layers | sensor domains | H-group |
| T1101-D1 | Eukaryota | TBM-easy | a+b two layers | KH-domains | H-group |
| T1101-D2 | Eukaryota | TBM-easy | beta barrels | LigT-related | Family |
Table 1. CASP14 target EU information. Taxonomic group, assessment class, and ECOD hierarchy: ECOD Architecture retains similar secondary structure compositions and geometric shapes, ECOD name assignment to X-groups that display similar topology but lack justification for homology, H-groups with homologous folds, or “na” for new folds, with hierarchy level in last column.