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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Immunol Rev. 2021 Aug 17;304(1):77–96. doi: 10.1111/imr.13019

FIGURE 2.

FIGURE 2

Summary of RNA regulatory mechanisms that control IFN and ISGs expression. Type I and III IFN signaling leads to the activation of the ISGF3 transcription factor complex and the expression of antiviral ISGs. RNA-binding proteins (RBPs) or alternatively spliced (AS) proteins, lncRNAs, and miRNAs that modulate this pathway are labeled in black, red, and blue, respectively