Table 3:

Vital Sign Change During 6MW (Adjusted for Walk Distance) and Survival in Adult Patients with SCD.

	n (%)	Crude Hazard ratio (95%CI, P value)	Hazard ratio adjusted for TRV and NT-pro BNP (95%CI, P value)
SBP increase*	480 (77)	0.68 (0.28–1.65, 0.39)	0.28 (0.10–0.81, 0.019)
DBP increase*	364 (58)	0.85 (0.37–1.96, 0.70)	0.72 (0.26–2.02, 0.54)
Pulse BP increase*	428 (68)	1.28 (0.50–3.26, 0.61)	0.91 (0.33–2.49, 0.85)
Oxygen % decrease**	309 (50)	1.42 (0.60–3.35, 0.43)	1.06 (0.40–2.82, 0.92)
Heart rate increase*	565 (90)	2.40 (0.33–17.61, 0.39)	1.15 (0.16–8.54, 0.89)

^*Was defined as any increase in vital sign from before to after 6MWT

^**Was defined as any decrease in O2 saturation from before to after 6MWT