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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Trends Neurosci. 2021 Oct 27;44(12):977–989. doi: 10.1016/j.tins.2021.10.003

Figure 2. Schematic of superimposed differentiation patterns in human hippocampal formation.

Figure 2.

A tripartite subdivision corresponding to a head, body and tail along the longitudinal axis is suggested by task-based and resting-state functional connectivity patterns. MRI-based estimates of local microstructural and macrostructural features in turn highlight a medial-lateral and ventro-dorsal differentiation separating the CA complex from the subiculum complex, as well as intrinsic medial-lateral gradients (within subfield gradients). Finally, the head shows a specific whole brain structural covariance in population cohorts. Superimposing these multiple differentiation patterns provide a holistic model to better understand hippocampal function and implications for clinical phenotypes.