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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Trends Neurosci. 2021 Oct 27;44(12):977–989. doi: 10.1016/j.tins.2021.10.003

Figure 3. Relationships between hippocampal organization and functional brain organization at the macroscale.

Figure 3.

Anterior and posterior subregions (see Figure 1) show different preferential coupling across the brain (top left panel, from [11]). In particular, the differentiation along the anterior-posterior axis is primarily related to a transmodal to sensory primary gradient of cortical organization (bottom left panel, from [23]). In contrast, iso to allocortical organization (i.e. latero-medial differentiation) within the medial temporal lobe (MTL) is strongly related to a cortical “multiple-demand” functional gradient (right panel, from [23]). The main organizational dimensions of the hippocampal formation are hence differentially related to the organizational dimensions of the rest of the human brain.