TABLE 4.
Pregnancy complications | TTP | ||||
---|---|---|---|---|---|
Platelet counts/μL | Preeclampsia (N = 774) | HELLP (N = 54) | Eclampsia (N = 10) | Acquired (N = 90) | Hereditary (N = 23) |
≥100 000 | 722 (93%) | 15 (28%) | 8 (80%) | 1 (1%) | 0 |
80–99 000 | 18 (2%) | 12 (22%) | 2 (20%) | 0 | 0 |
60–79 000 | 15 (2%) | 11 (20%) | 0 | 2 (2%) | 1 (4%) |
30–59 000 | 13 (2%) | 12 (22%) | 0 | 1 (1%) | 6 (26%) |
10–29 000 | 5 (1%) | 4 (8%) | 0 | 46 (51%)3 | 16 (70%) |
<10 000 | 1 (0.1%) | 0 | 0 | 40 (45%)4 | 0 |
Note: The total number of patients in each column is presented in parentheses. Data for the women with pregnancy complications are also presented in Tables 2 and 3. For women with pregnancy complications, the platelet counts are the lowest count at delivery, ±2 days. Data for acquired TTP are from the 90 consecutive patients (23 men, 67 women) enrolled in the Oklahoma TTP Registry, 1995–2018. The data are from the patients’ first episode, the most abnormal value among platelet counts measured on the day of the first plasma exchange treatment ±7 days. Seven of the 67 women whose initial episode of TTP occurred during pregnancy or postpartum (Table 3) are indicated by the superscript numbers.3 Data for hereditary TTP are from 23 women who had severe complications of pregnancy, described in our review of case reports.7