Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2022 Dec 1.

Published in final edited form as: Neurobiol Aging. 2021 Jun 24;108:24–33. doi: 10.1016/j.neurobiolaging.2021.06.007

Table 2 A&B:

Multiple regression for the relationship between RMT and ADAS-Cog in AD participants in (A) discovery and (B) validation cohorts

A) Discovery Cohort
Models with covariates^*	df	β _RMT	%β_RMT^†	Adj.R²_model	partial R²_covar^‡	p_model	p_RMT	p_covar	Corrected p_model	Corrected p_RMT	Corrected p_covar
RMT & Age	2,19	−0.73	−4.29	0.46	0.03	< 0.001	< 0.001	0.446	< 0.001	< 0.001	1.000
RMT & Gender	2,19	−0.67	4.29	0.51	0.11	< 0.001	< 0.001	0.140	< 0.001	< 0.001	0.700
RMT & Hand-dominance	2,18	−0.7	0	0.43	0.00	0.001	0.001	0.960	0.002	0.003	1.000
RMT & ApoE- ε4	2,9	−0.68	2.86	0.34	0.31	0.022	0.022	0.924	0.022	0.022	1.000
RMT & AD Medication Status	2,18	−0.69	1.43	0.48	0.06	< 0.001	< 0.001	0.301	< 0.001	< 0.001	1.000
RMT & SCD	2,19	−0.83	−18.57	0.58	0.25	< 0.001	< 0.001	0.022	< 0.001	< 0.001	0.154
RMT & left motor cortex CT	2,19	−0.62	11.43	0.54	0.17	< 0.001	0.001	0.060	< 0.001	0.003	0.360
B) Validation Cohort
RMT & Age	2,125	−0.35	0	0.13	0.02	< 0.001	< 0.001	0.095	< 0.001	< 0.001	0.190
RMT & Gender	2,126	−0.35	0	0.11	0.00	< 0.001	< 0.001	0.829	< 0.001	< 0.001	0.829
RMT & AD Medication Status	2,126	−0.36	−2.86	0.13	0.03	< 0.001	< 0.001	0.048	< 0.001	< 0.001	0.144

^*

Covariables were used in separate models to check their individual influence on the relationship.

^†

%Δβ > 10 is the tolerance threshold for influence.

^‡

Partial R²_covar measures the additional covariance explained by each factor.