Figure 4.

Venn diagram of GO-BP term (a) and pathways (b) enriched by genes identified by top ML sparse classifiers across all etiological testing sets. (a) Twenty-five enriched GO-BP terms were shared specifically for BRSV and IBR, primarily consisting of apoptotic processes, type 1 interferon signaling, IL-8 secretion, and leukocyte degranulation. BVDV possessed only one enriched GO-BP term (anatomical structure homeostasis) and no GO-BP terms were enriched for M. bovis. (b) Eight enriched pathways were shared specifically across BRSV and IBR, primarily consisting of antigen cross presentation, uptake of ligands by scavenger receptors, and interferon alpha/beta signaling. The four pathways shared across BRSV, IBR, and M. haemolytica involved the innate immune system, stress response element binding via ATF6-alpha, and signal recognition protein-dependent protein translation. The eight enriched pathways specific to M. haemolytica involved alternative complement activation, MHC class I antigen presentation, cellular response to heat stress, and IRE1-alpha-dependent chaperone activation. No pathways were enriched for BVDV or M. bovis.