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. 2021 Nov 25;12:6891. doi: 10.1038/s41467-021-27273-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Illustration of Stat3 deletion in Osx-expressing pre-osteoblasts. b Western blotting of STAT3 in BMSCs from 4-week-old male Stat3^fl/fl and Osx^Cre;Stat3^fl/fl mice cultured in osteogenic medium for 7 days. The experiment was performed twice to similar results. c Representative views of 8-week-old male Osx^Cre and Osx^Cre;Stat3^fl/fl mice. d–f Skeletal preparations from male Osx^Cre and Osx^Cre;Stat3^fl/fl newborns were double-stained with alcian blue and alizarin red S. Arrows indicate calvarial lesions. g Microcomputed tomography (micro-CT) images of skulls from 4-week-old male Osx^Cre and Osx^Cre;Stat3^fl/fl mice. Arrows indicate calvarial lesions. h Micro-CT images of distal femurs from 4-week-old male Osx^Cre and Osx^Cre;Stat3^fl/fl mice. i–m Quantitative parameters of micro-CT, including bone volume per tissue volume (BV/TV), trabecular thickness (Tb.Th.), trabecular number (Tb.N.), trabecular space (Tb.Sp.), and cortical thickness (Ct.Th). n = 7. Two-tailed Student’s t test. Data represent the mean ± s.d. Source data are provided in the Source data file.