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. 2021 Nov 25;12:6867. doi: 10.1038/s41467-021-27018-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a UMAP plots showing subclusters of malignant cells in each cancer subtype, donor effect corrected by Harmony. b Heatmap showing signature genes for each malignant cell subcluster in EPN. Selected genes were labeled on the right side. c Scatter plots showing average expression of 12 generic tumor cell programs in each malignant subset in EPN. The boxes highlight programs which were expressed in specific subsets. d Bar plot showing different pathways enriched in VEGFA⁺ C4 and other clusters from EPN scored per cell by gene set variation analysis (GSVA). t values were calculated with limma regression. e Density plot showing the entropy of patient distribution for malignant cells in each cancer subtype. f Circular bar plot showing the number of targetable genes from different categories in each cancer subtype. g Venn plots showing the intersection of targetable genes in astroependymal-like and NSC-like subpopulations across different cancer subtypes. The shared genes between the three cancer subtypes are listed on the right side. h Bar plot showing the number of targetable genes from different categories in VEGFA⁺ subpopulation of EPN. Source data are provided as a Source Data file. See also Supplementary Fig. 5 and Supplementary Data 6 and 7.