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. 2021 Nov 25;12:6896. doi: 10.1038/s41467-021-27210-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Pretreatment with ABT263 or VHL-L blocks the BCL-xL/2 degradation induced by 753b in 293T cells. b CRISPR knockout of VHL blocks 753b-induced BCL-xL/2 degradation as shown in wild type (WT) and VHL knockout (VHL-ko) 293T cells. c Inhibition of CRL^VHLneddylation with MLN4924 blocks BCL-xL/2 degradation induced by 753b in 293T cells. d Inhibition of proteasomes with MG132, but not that of caspases with the pan-caspase inhibitor QVD, blocks 753b-induced BCL-xL/2 degradation in 293T cells. Source data are provided as a Source data file.