Fig. 6. Summary of functional abnormalities in tasks probing (a) reward-related processes and (b) negative processing biases in major depressive disorder (MDD).

Regions highlighted in orange and blue show higher activation and lower activation, respectively, in MDD samples than healthy controls (HC). Orange and blue arrows denote higher and lower functional connectivity, respectively, in MDD samples than healthy controls. AMG amygdala, dACC dorsal anterior cingulate cortex, dlPFC dorsolateral prefrontal cortex, mPFC medial prefrontal cortex, pgACC perigenual anterior cingulate cortex, sgACC subgenual anterior cingulate cortex, Striat Striatum vmPFC ventromedial prefrontal cortex.