Table 1.

Summary of frontostriatal abnormalities in MDD in tasks probing different reward-related processes.

	Reward consumption	Reward anticipation	Reward learning
A. Hypo-activation
Ventral and Dorsal Striatum	↓ (greater ↓, higher anhedonia)	↓ (greater ↓, higher anhedonia & more transition to MDD)	↓ (greater ↓, higher anhedonia & higher anhedonia 6 months later)
pgACC	↓ (greater ↓, higher depressive symptoms)	↓	↓
dACC	↓
Medial OFC	↓	↓ (greater ↓, higher anhedonia)	↓ (greater ↓, higher anhedonia)
B. Hyper-activation
mPFC	↑	↑
vmPFC (subgenual PFC)	↑ (greater ↑, higher anhedonia & more future MDD)
dlPFC	↑	↑
Lateral OFC		↑ to non-rewards (greater ↑, more future MDD)