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. 2021 Nov 25;11:22911. doi: 10.1038/s41598-021-02308-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cytokine and chemokine production in the MTX-induced mucositis organoids. Organoids were treated with 10, 100 and 1000 ng/mL MTX and incubated for 96 h. At different time points supernatant was collected and CXCL10 (A), CCL5 (B), TNF-α (C) and IL-1β (D) measured by Multiplex Immunoassay (n = 4). All data are presented as mean ± SEM. * (p < 0.05), ** (p < 0.01) and *** (p < 0.001) represent the significant changes between the MTX-treated and untreated groups.