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. 2021 Nov 25;12:6832. doi: 10.1038/s41467-021-27215-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Cumulative incidence of hospital death in the combined cohort (a), in the subgroup of children with P. falciparum malaria (b) and without malaria (c), stratified into the “green”, “yellow”, “red” sTREM-1 zones. sTREM-1 cut-off values were generated using a LR− of 0.10 (<239 pg/mL) and LR+ of 10 (≥629 pg/mL) derived in the derivation and validation cohorts combined corresponding to the mortality risk zones. Time-to-event curves were plotted based on Kaplan–Meier estimates. Wald test was used to calculate P-values for differences between zones.